Give your opinion!
In a few months, a new add-on medication specifically developed to provide a quick and effective response to greater difficulty with movement and intense fatigue (OFF periods) will be available on pharmacy shelves. For this drug to be reimbursed, patient organizations must demonstrate that there is a need for this new type of drug.
Do you or your loved one, experience alternating periods between ON periods where the symptoms are well managed and OFF periods where the treatment is no longer effective, and the symptoms are very disabling?
Give us your opinion on the importance of the usefulness of this drug.
What are ON/OFF alternations in Parkinson’s disease?
These alternations depend on the effectiveness of your dopaminergic treatment that varies according to the time of day: You have periods of mobility that are interspersed with phases of akinesia (blocked movements, difficulty walking and risk of falling). During OFF periods, you may have less mobility, and feel intensely fatigued.
These OFF periods have nothing to do with the freezing phenomenon, refers to transient episodes, usually lasting seconds, in which the motor activity being attempted is halted (i.e. feet seem “glued” to the floor).
When do OFF periods occur?
Usually after five to ten years of treatment. OFF periods can occur:
- When your levodopa medication takes time to start working, mainly in the morning.
- When your levodopa medication sometimes provides a partial effect
- When your levodopa medication fails to provide any effect at all
- When it is time for your next dose and the effect of your levodopa medication wears off too soon.